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KMID : 0376219860230010113
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Chonnam Medical Journal
1986 Volume.23 No. 1 p.113 ~ p.120
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Correlation of Clinical Spirometric Parameters and Arterial Blood Gas Analysis in Obstructive Lung Disease
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Abstract
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Obstructive lung disease such as bronchial asthma, chronic bronchitis, and emphysema result in typical changes in pulmonary function tests, including reduced airflow rate (FEV1 and MMFR), decreased vital capacity, increased lung volume, and abnormal gas exchange.
In order to define the clinical correlation of Pa02 and PaCO2 with the degree of airway obstruction measured by pulmonary function tests in acute and chronic obstructive lung disease, correlation between clinical spirometry and arterial blood gas analysis of 23 patients with bronchial Asthma and 38 patients with chronic obstructive lung disease were evaluated. The results were as follows:
1. When the severity of obstructive lung disease estimated by arterial blood gas analysis was examined in relationship to pulmonary function tests, mean values of clinical spirometry parameters decreased gradually with increasingly severe stages of disease.
2. Maximal mid-expiratory flow rate (FEF25-75%) decreased markedly compared with FEV1, and a noticeable diminution of Vmax50 and Vmax75 showed a "scooped out" pattern in maximal expiratory flow volume curve with increasingly severe stage of disease.
3. Significant positive correlation (r = 0.609) between Pa02 and FEV1 and negative correlation(r=-0.586) between PaCO2 and FEV1 were found in obstructive lung disease except for emphysema group.
4. There were no significant differences in the changes of mean values of FEV1, in each stage of severity estimated by blood gas analysis between bronchial asthma and chronic obstructive lung disease groups.
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KEYWORD
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